Organoid - Wikipedia
An organoid is a miniaturised and simplified version of an organ produced in vitro in three dimensions that mimics the key functional, structural, and biological complexity of that organ. [1] It is derived from one or a few cells from a tissue , embryonic stem cells , or induced pluripotent stem cells , which can self-organize in three ...
Organoids - Nature Reviews Methods Primers
2022年12月1日 · Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue.
Human organoids: model systems for human biology and medicine
2020年7月7日 · Human organoids have been used to study infectious diseases, genetic disorders and cancers through the genetic engineering of human stem cells, as well as directly when organoids are generated...
Organoids: A new window into disease, development and discovery
2017年11月7日 · Organoids are tiny, self-organized three-dimensional tissue cultures that are derived from stem cells. Such cultures can be crafted to replicate much of the complexity of an organ, or to express selected aspects of it like producing only certain types of cells.
What Is an Organoid? - ScienceAlert
Organoids are small, simplified, 3D copies of organs created outside of a living body, usually grown by treating combinations of tissues or stem cells with the nutrients and chemical signals (growth factors) that encourage them to differentiate and self-organize.
Human organoids in basic research and clinical applications
2022年5月24日 · Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from healthy...
Organoids: development and applications in disease models, drug ...
Organoids are miniature, highly accurate representations of organs that capture the structure and unique functions of specific organs.
Organoids — Preclinical Models of Human Disease
2019年2月6日 · An organoid is a three-dimensional construct composed of multiple cell types that originates from stem cells by means of self-organization and is capable of simulating the architecture and...
Advances in cardiac organoid research: implications for …
2025年1月18日 · Recent advances in cardiac organoid research have been significant. The cardiac organoids developed by Hofbauer and colleagues utilize high-throughput methods to optimize signaling conditions and integrate three primary cardiac lineages, improving reproducibility and allowing for chamber-like morphogenesis without non-cardiac tissues . This …
Organoids: The current status and biomedical applications
Organoid culture is an emerging 3D culture technology, and organoids derived from various organs and tissues, such as the brain, lung, heart, liver, and kidney, have been generated. Compared with traditional bidimensional culture, organoid culture systems have the unique advantage of conserving parental gene expression and mutation ...