Neuronal Development: Rethinking sensorimotor circuits | eLife
2024年11月13日 · For decades, scientists have theorised that motor neurons have an essential role during the development of sensorimotor circuits that involves specifying the fate of the projection neurons (Glover, 2000; Glover, 2003).This ‘retrograde specification model’ was in part inspired by the observation that extraocular motor neurons establish connections with muscle cells before projection neurons ...
The promise and peril of comparing fluorescence lifetime in …
2024年11月12日 · Figure 2. Simulated fluorescence lifetime in brain tissue. (A) Simulated example histograms (upper panels) and heatmaps (middle and lower panels) showing the average fitted P 1 and empirical lifetime of the simulated data across a range of P 1 and sensor photon number conditions. Fluorescence lifetime histograms were simulated with the sensor only, sensor + autofluorescence (autoF), and sensor ...
Research Articles - eLife
3 天之前 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
Science Forum: Antibody characterization is critical to enhance
2024年8月14日 · Antibodies are critical reagents used in a variety of assays and protocols in biomedical and clinical research. The ability to detect, quantify, enrich, localize, and/or perturb the function of a target protein – even when present in a complex protein mixture, such as a cell lysate or tissue slice, or even in an intact organism – is key to many biomedical research studies.
Submit your research · eLife
eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd ...
About | eLife Assessments · eLife
eLife changed its approach to peer review in 2023 to better convey the assessments made by editors and reviewers. Every Reviewed Preprint published in the journal now includes an eLife Assessment written by the editor who oversaw the review process and the peer reviewers.
About - eLife
eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science.
How to measure and evaluate binding affinities | eLife
2020年8月6日 · First, we asked if equilibration was demonstrated. By definition, an equilibrium state is invariant with time. So, determining a binding equilibrium constant requires showing that there is no change in the amount of bound complex over time.
Luminal epithelial cells integrate variable responses to aging into ...
2024年11月15日 · One of the main risk factors for breast cancers is aging. But how exactly aging contributes to breast cancer is not fully understood. The mammary gland is the part of the breast that can produce milk, and is composed of two major cell types: luminal epithelial cells and myoepithelial cells. Most age-related breast cancers are thought to originate from luminal epithelial cells, but some age ...
Hematopoiesis: Counting blood precursors - eLife
2024年7月17日 · Experiments with the Confetti reporter system in mice revealed that hundreds of HSPCs in the embryo contribute to hematopoiesis in adults, and that expansion of these precursors is limited in the fetal liver (Ganuza et al., 2017; Ganuza et al., 2022).However, the previous mathematical model used to quantify the number of precursors was only tested for cell counts between 50 and 2,500 cells ...