Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution. It can be defined as any duplication of a region of DNA that contains a gene.

Gene duplication is an important evolutionary mechanism allowing to provide new genetic material and thus opportunities to acquire new gene functions for an organism, with major implications such as speciation events.

4 天之前 · Duplication, as related to genomics, refers to a type of mutation in which one or more copies of a DNA segment (which can be as small as a few bases or as large as a major chromosomal region) is produced. Duplications occur in all organisms.

2024年11月23日 · Gene duplication is the process by which a region of DNA coding for a gene is copied. Gene duplication can occur as the result of an error in recombination or through a retrotransposition event. Duplicate genes are often immune to the selective pressure under which genes normally exist.

In genetic approaches to duplication mechanisms, one measures the rate of duplication formation and observes how that rate is affected by mutations that eliminate various candidate functions. This requires observing changes in duplication frequency over time.

Gene duplication is an important mechanism for acquiring new genes and creating genetic novelty in organisms. Many new gene functions have evolved through gene duplication and it has contributed tremendously to the evolution of developmental programmes in various organisms.

2010年1月6日 · This comprehensive Review of theoretical models of gene-duplication evolution and the data that can distinguish between them provides a foundation for answering these crucial questions.

Duplication of genetic material is clearly a major route to genetic change, with consequences for both evolution and disease. A variety of forms and mechanisms of duplication are recognised, operating across the scales of a few base pairs upto entire genomes.

2023年12月20日 · A duplicate gene is a gene that has been duplicated through a process called gene duplication. Gene duplication occurs when an organism’s DNA makes an exact copy of a gene, resulting in two copies of the same gene.

2004年7月13日 · Gene duplication provides opportunities to explore this forbidden evolutionary space more widely by generating duplicates of a gene that can ‘wander’ more freely, on condition that between them they continue to supply the original function.