Ca2+ releases E-Syt1 autoinhibition to couple ER-plasma …
2018年1月17日 · Using liposome-based assays, we show that Ca 2+ binding to C2C promotes E-Syt1-mediated membrane tethering by releasing an inhibition that prevents C2E from …
ESYT1 tethers the ER to mitochondria and is required for
2023年11月6日 · Loss of the ESYT1-SYNJ2BP complex impaired ER to mitochondria calcium flux and provoked a significant alteration of the mitochondrial lipidome, most prominently a …
Ca2+ releases E‐Syt1 autoinhibition to couple ER‐plasma …
2017年12月8日 · Using liposome‐based assays, we show that Ca 2+ binding to C2C promotes E‐Syt1‐mediated membrane tethering by releasing an inhibition that prevents C2E from …
麦吉尔大学:ESYT1将内质网束缚在线粒体上，是线粒体脂质和钙稳 …
2024年1月1日 · 研究人员使用了多种技术，包括近距离标记（BioID）、共免疫沉淀、共聚焦显微镜和亚细胞分离等，发现 ER 中的膜蛋白 ESYT1 在线粒体-ER 接触点（MERCs）处富集，并 …
ESYT1 protein (human) - STRING interaction network
ESYT1: Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and …
E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER ... - Nature
2019年3月8日 · With home-built super-resolution microscopes that provide superior axial and lateral resolution in live cells, we revealed that extracellular Ca 2+ influx via SOCE activated E …
Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable …
2016年6月27日 · In the cKO mice, Cre recombination will lead to deletion of exon 10, causing a frameshift in the protein and insertion of an early stop codon. Moreover, in the ESyt1 line, the …
Super-resolution insights into the role of Esyt1 in ER-PM junction ...
2024年2月8日 · Supporting these observations, super-resolution stimulated emission depletion (STED) imaging (resolution ≈ 50 nm) demonstrated a trend in the subpopulation of ANO1 and …
扩展突触结合蛋白 1（ESYT1）基因 | MCE - MCE-生物活性 ...
Enables identical protein binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Located in endoplasmic reticulum. Is integral …
STIM1 moonlights as an anchor for STING - Nature Immunology
2019年1月14日 · Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been …