DNA-binding C2H2 zinc finger proteins also regulate RNA processing, researchers discover
C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...
Nature5y
Monocytic leukemia zinc-finger protein MOZ and its related factor MORF are new histone acetyltransferases
The monocytic leukemia zinc-finger protein (MOZ) gene is rearranged in t(8; 16)(p11; p13) and inv(8)(p11q13) associated with acute myeloid leukemia. The other fusion partners involved are CBP and ...
The Scientist10mon
An Epigenetic Strategy to Control Bad Cholesterol
After testing the targeting capabilities of several different DNA binding domains, the team settled on a zinc finger protein—a little curlicue-shaped protein that performed the best in terms of ...
Hosted on MSN1mon
Could a pill replace gene therapy for sickle cell disease? Research uncovers potential path to small-molecule drug
It does so with the help of a zinc finger, a small protein wrapped around a zinc molecule. Orkin's team has now reported the crystal structure of the BCL11A tetramer and suggested several ways to ...
BioWorld3d
Xaicure Pharmaceuticals discovers new KAT6A and KAT6B inhibitors
Co. Ltd. has described histone acetyltransferase KAT6A (monocytic leukemia zinc finger protein; MOZ; MYST-3) and/or histone acetyltransferase KAT6B (MOZ2; MYST-4) inhibitors reported to be useful for ...
Nature1y
Do Transcription Factors Actually Bind DNA? DNA Footprinting and Gel Shift Assays
Sp1 is a protein that has multiple zinc-finger motifs, or regions known to bind to zinc; however, the inclusion of EDTA, an agent that chelates metal ions, inhibits zinc binding. Thus, notice that ...
BioWorld28d
Canary Cure’s CCT-217 demonstrates fat loss and lean body mass preservation in preclinical studies
Canary Cure Therapeutics (Canary Global Inc.) has released preclinical results for its lead candidate, CCT-217, an siRNA therapeutic targeting cannabinoid CB1 receptor (CB1R) and zinc finger protein ...