Researchers studying gene expression have access to vast amounts of data from cells or tissues. This is thanks to advances in ...

Chronic diseases such as cancer, arthritis, and fibrosis are the leading causes of death and disability worldwide. Recent findings have highlighted that RNA processing is systematically altered in ...

Several mechanisms have evolved that regulate the biogenesis of specific classes of small RNA using variations on the same core processing machinery. Most animals encode a single Dicer protein ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

The aim was to create a standard RNA-seq pipeline that included quality controls, alignment and post-processing. The pipeline has been developed using Snakemake, a tool to create reproducible and ...

Most of these proteins are RNA-binding proteins that are involved in distinct steps of RNA processing, maturation, transport and the regulation of RNA stability and translation. Interestingly ...

Alternative pathways of RNA processing are regulated in response to signaling cues often coordinating expression of gene networks in response to physiological change including in development and ...

This project provides a comprehensive and modular RNA-Seq data processing pipeline, automating quality control, read trimming, alignment, and coverage quantification. The pipeline ensures efficient, ...

A new study from the Kowalinski group at EMBL Grenoble characterized the structure of an important trypanosomal protein ...

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies protein synthesis and impacts RNA processing in Alzheimer's ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other ...