A midsystolic murmur begins just after the S1 heart sound and terminates just before the P2 heart sound; thus, S1 and S2 will be distinctly audible. Conversely, a holosystolic murmur begins with ...

often the S1 and S2 sounds are overwhelmed by the murmur and may be difficult to hear. The murmur of mitral regurgitation is described as a high-pitched, "blowing" holosystolic murmur best heard ...