The superfamily 1 (SF1) and SF2 enzymes are non-hexameric enzymes possessing both helicase and single-stranded DNA (ssDNA) translocase activities, as well as the ability to displace proteins from DNA.

Tuesday, shares of Ideaya Biosciences (NASDAQ:IDYA), trading at $22.18 near its 52-week low of $22.10, drew attention as BTIG analysts maintained their Buy rating and $62.00 price target. According to ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Homologous recombination (HR) is important for ...

Distinguishing between firing of the displaced versus the non-displaced Mcm complexes is important to test our hypothesis that displacement of the helicase complex into a relatively nucleosome-free ...

This valuable study is a detailed investigation of how chromatin structure influences replication origin function in yeast ribosomal DNA, with a focus on the role of the histone deacetylase Sir2 and ...

To our knowledge, there are no existing investigations employing a separation protocol resembling the helicase dissociation process of DNA. Helicases break hydrogen bridges in a helicoidal-sequence ...

and SCLC patient case study IDE275 (GSK959), a potential first-in-class Phase 1 Werner Helicase program targeting MSI-high solid tumors Targeting presentation at a medical conference with GSK ...

The company announced the completion of an investigational new drug (IND) application submission for NDI-219216, a novel Werner syndrome helicase (WRN) inhibitor in development for the treatment ...

It has been argued that the F-type ATPases emerged as a modular enzyme that was formed by the combination of an RNA or DNA helicase and a proton channel 32,33. In this Opinion, we examine the ...