DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides—whether to repair damaged tissue, replace old cells, or simply to help the ...

Scientists at the Wellcome Sanger Institute uncovered DNA damage that can persist for years, evading repair mechanisms and ...

DNA damage can result in the genetic sequence being misread and copied during cell division—known as DNA replication—and this introduces permanent mutations that can contribute to the ...

checkpoint abrogation can induce cell death or further sensitize cancer cells to other genotoxic therapies. Particularly aberrant Cdk1 activation at the G2/M checkpoint by kinase inhibitors causing ...

Combining long-read DNA sequencing with a predictive artificial intelligence model has provided new insights into DNA ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell ...

The transfer of this principle to artificial cells is a challenge in synthetic biology. Advances in DNA nanotechnology now offer promising solutions. They allow the creation of novel transport ...

Most dividing cells in the body have well-defined checkpoint mechanisms to sense and correct DNA damage during DNA replication. Neurons, however, do not divide. For this reason, they are at ...

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells that can remain unrepaired for years. While most types of DNA damage are ...

In addition, HIV CD4 T cells were prone to DNA damage that extended to chromosome ends—telomeres ... HIV subjects were virologically suppressed for HIV replication with cART, as evidenced by an ...