GENFI Top Hits. CSF proteomics linked abundance of CALB2, GRN/NAGA, and PEA15/SEMA6A to C9ORF72 (gold), GRN (red), and MAPT ...

Here, we will examine the experimental evidence regarding the direct and indirect pathways through which astrocytes and microglia can alter brain plasticity in AD, specifically as they relate to the ...

New research uncovers how declining protein clearance mechanisms with age lead to Alzheimer’s, Parkinson’s, and other ...

This transgenic model of tauopathy expresses MAPT with the P301S mutation, which is associated with autosomal-dominant disease in humans. The hTau.P301S model recapitulates several molecular, cellular ...

Rainwater Prizes honor researchers worldwide who are advancing discoveries for diseases caused by tau protein accumulations ...

Recent research from Stony Brook Medicine shows that early signs of dementia are becoming more frequent among first ...

"However, the sequence of events and the form of tau that confers toxicity are still unclear, due in large part to the lack of physiological models of tauopathy initiation and progression in which ...

Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles are eliminated. Beyond this homeostatic function, autophagy is ...

在一项新的研究中，来自布莱根妇女医院和圣路易斯华盛顿大学医学院的研究人员揭示了一种前所未有的治疗阿尔茨海默病的方法—— 吸入氙气（xenon）。这种惰性气体不仅能够抑制神经炎症、减少大脑萎缩，还能增加保护性的神经元状态。

The diagnosis of Parkinson's disease and atypical Parkinsonism remains clinically difficult, especially at the early stage of the disease, since there is a significant overlap of symptoms. Multimodal ...

Gene expression is the generation of a functional gene product from the information encoded by a gene, through the processes of transcription and translation. Gene products are often proteins ...

在一项新的研究中，来自布莱根妇女医院和圣路易斯华盛顿大学医学院的研究人员揭示了一种前所未有的治疗阿尔茨海默病的方法——吸入氙气（xenon）。这种惰性气体不仅能够抑制神经炎症、减少大脑萎缩，还能增加保护性的神经元状态。相关研究结果发表在2025年1月 ...