Toolkit for highly memory efficient analysis of single-cell RNA-Seq, scATAC-Seq and CITE-Seq data. Analyze atlas scale datasets with millions of cells on laptop. CREsted is a Python package for ...

CREsted is a Python package for training sequence-based deep learning models on scATAC-seq data, for capturing enhancer code and for designing cell type-specific sequences.

Simulation data settings for all experiments; each cluster contains 500 cells; ‘*’ refers to the variable parameter. To adapt scCTClust on SNARE-seq data, we converted the peak level count matrix of ...

Understanding how cells transform into specialized types during human development is a central challenge in biology. This ...

Understanding how cells transform into specialized types during human development is a central challenge in biology. This ...

随着单细胞表观基因组技术的发展，单细胞染色质可及性测序（scATAC-seq）产生了大量数据，有助于研究细胞间的异质性，但该技术无法提供细胞的空间信息。而新兴的空间表观基因组技术，如 spATAC-seq，能够同时提供染色质可及性和空间位置信息，使研究人员 ...

The expanding development of multi-modal single-cell sequencing technologies affords newer platforms to elucidate the mechanisms underlying these processes at unprecedented resolution. Furthermore, ...

Design Genome-wide DNA methylation analysis was conducted by EPIC BeadArray using IM crypts isolated by Alcian blue staining. Chromatin immunoprecipitation sequencing for H3K27ac and single-cell assay ...

单细胞和空间组学的未来方向 目前，在单细胞和空间组学领域，华大单细胞技术DNBelab C4技术平台基于高通量单细胞建库系统，联合自主研发的DNBSEQ超高通量测序系统，可以实现单次测序数据产出规模达百万级细胞，可用于检测scRNA-seq及scATAC-seq，在大幅降低建库 ...