an RNA structure normalization tool used in RNA-Puzzles. the RNA 3D structure comparison metrics used in RNA-Puzzles assessment, including RMSD (all-atom), P value, Interaction Network Fidelity and ...

UMD researchers have discovered key mechanisms in gene regulation that could improve the design of RNA-based medicines.

RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA ...

UMD researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines.

Biologically active RNAs, including transport, ribosomal and small nuclear RNA (tRNA, rRNA, snRNAs) fold into unique structures guided by complementary pairing between nucleotide bases.

这在很大程度上受到了过去 60 多年关于 RNA 结构的错误观念的影响。王运星实验室的研究结果颠覆和更正了这些观念，并提出了用“准等能量”分子构象转换概念，来概括全新的 RNA 分子在溶液中的行为。

A sophisticated molecular machine, the spliceosome, ensures the accurate assembly of genetic information from the genome into ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

1958年，弗朗西斯・克里克提出了中心法则，提出遗传信息从 DNA 转录为 RNA，再经翻译指导蛋白质合成，随后蛋白质参与生命活动这一流程，看似一气呵成，实则存在问题。 若仔细观察，便会发觉此流程不够简洁，RNA 的存在略显累赘。毕竟，越简单的系统往往越高效、越易实现，繁琐的系统则耗能多且不易形成。 从结构看，RNA 与 DNA ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...

A team of researchers from the Keck School of Medicine of USC has unlocked the details of a cellular pathway that triggers ...

By treating DNA as a language, Brian Hie’s “ChatGPT for genomes” could pick up patterns that humans can’t see, accelerating ...