The phylogenetic overlays or ideograms (Figures 6 and 7) in part show the complexity of the evolution and organisation of the primate MHC genes via the orthologous and paralogous gene and species ...

Moreover, the exclusive criteria were variants that appeared in a large proportion of genes and in highly paralogous genes. We used the R package “dNdScv” (Martincorena et al., 2017) to identify ...

This valuable manuscript presents a thorough analysis of the evolution of Major Histocompatibility Complex gene families across Primates. A key strength of this analysis is the use of state-of-the-art ...

Feb. 6, 2025 — Despite new medication, cystic fibrosis often leads to permanent lung damage. Researchers have discovered that the disease causes changes in the immune system early in life ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

High concentrations of antibiotics in antibiotic production wastewater can cause the widespread transmission of antibiotic resistance genes (ARGs). Here, we collected a set of time series samples from ...

Gene expression is the generation of a functional gene product from the information encoded by a gene, through the processes of transcription and translation. Gene products are often proteins ...

This happens through a process called epigenetics, whereby certain genes are expressed to a greater or lesser extent depending on a person’s surroundings. Abused children, for instance ...

Types 1 and 2 diabetes appear to be caused by an interplay of genetic, environmental, and lifestyle factors. Over the years, researchers have found an array of specific genes that are linked to ...

Significant gene variants were found in the loci DRD2, FURIN, and CYP7B1, which play a part in neuroinflammation, neurosteroid synthesis, and synaptic function.

Department of Chemistry, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana−Champaign, ...