The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

LIG4 syndrome is an exceptionally rare disorder caused by a genetic mutation that prevents the body from repairing damaged ...

During DNA replication ... bind to both enzymes. However, that requires us to understand the molecular architecture of DNA helicase. Coordination of DNA Unwinding and Replication is Essential ...