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“Given the fact that the X chromosome is enriched for brain-related genes, it became very important for us to know what roles it might be playing in brain aging,” said Samira Abdulai-Saiku, PhD, a ...

Males, with their single X chromosome ... a DNA damage checkpoint, triggered by double-strand break formation, leading to defects like chromosome fraying and fragmentation. Consequently, this led to ...

Each chromosome contains short sections of DNA called genes. These genes carry the instructions that determine features, such as eye colour, hair colour, blood group and height. Our largest ...

Characteristics of CNVs A change in copy number requires a change in chromosome structure, joining two formerly separated DNA sequences ... of dosage-sensitive genes in particular regions ...

Three XX true hermaphrodites, RZ, PG, and AK, were studied for the presence of the Y chromosome sequences. All of them were positive for the SRY gene in a very limited region of Y DNA corresponding to ...

Older female mice show poor spatial memory when their paternal X chromosome is inactive ... to the genome that do not alter the DNA sequence but regulate gene expression. It prevents females ...

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with some showing considerable or complete skew of the X chromosome that remains active. Parent-of-X origin can modify epigenetics through DNA methylation and possibly gene expression; thus, mosaicism ...

Female mammals typically carry two X chromosomes ... genes themselves, she explained. This also enabled the team to pinpoint differences in epigenetics — chemical tags that attach to DNA ...

Until now, DNA and RNA epigenetics were studied as independent systems. These two mechanisms seemed to function separately, each playing its own role in distinct stages of the gene regulation process.