Human artificial chromosomes (HACs) and gene therapy represent a promising frontier in genetic research and treatment. HACs are engineered structures that can carry large segments of human DNA ...

Males, with their single X chromosome ... a DNA damage checkpoint, triggered by double-strand break formation, leading to defects like chromosome fraying and fragmentation. Consequently, this led to ...

Large and rare duplications and deletions in a chromosome ... segment of DNA varies in the genomes of different people. Several variants identified in the research involved the genes TBX1, CRKL ...

Maternal DNA, particularly the X chromosome, significantly influences a baby’s brain development and aging. Genetic variations and maternal vitamin D levels during pregnancy impact cognition, memory, ...

In this study, five very rare cases of SRY carrying subjects (two XX males and three XX true hermaphrodites) with various degrees of incomplete masculinisation were analysed in order to elucidate the ...

We suggest that replicative mechanisms might be particularly important, and discuss a potential relationship ... a change in chromosome structure, joining two formerly separated DNA sequences.

Background: DNA methylation played essential roles in regulating gene expression. The impact of DNA methylation status on the occurrence and development of cancers has been well demonstrated. However, ...

Until now, DNA and RNA epigenetics were studied as independent systems. These two mechanisms seemed to function separately, each playing its own role in distinct stages of the gene regulation process.

with some showing considerable or complete skew of the X chromosome that remains active. Parent-of-X origin can modify epigenetics through DNA methylation and possibly gene expression; thus, mosaicism ...

The DNA libraries were prepared with ... the probes for mapping the chain cytogenetic relationship for the BAC clones. By doing so, we constructed the cytogenetic map of S. spontaneum based on the 10 ...

Female mammals typically carry two X chromosomes ... genes themselves, she explained. This also enabled the team to pinpoint differences in epigenetics — chemical tags that attach to DNA ...