近期，哥本哈根大学诺和诺德基金会蛋白质研究中心的研究人员在npj Precision Oncology期刊上发表了一篇题为 “Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma” ...

A new drug delivery system shows promise for treating a rare, aggressive form of cancer affecting pregnant women and new mothers, and it has potential for other cancers as well. Scientists led by ...

LIG4 syndrome is an exceptionally rare disorder caused by a genetic mutation that prevents the body from repairing damaged ...

A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.

Onco-Innovations’ licensed technology demonstrates promise to enhance chemotherapy effectiveness by overcoming cancer cell resistance: Vancouver, BC Saturday, February 1, 2025, ...

ATR 激酶是应对 DNA 复制应激（RS）的关键调节因子，在癌细胞中，许多遗传突变会导致 RS 水平升高，而 ATR 在维持复制叉的稳定性和促进细胞存活方面发挥着重要作用。抑制 ATR 可使癌细胞因复制叉崩溃和有丝分裂灾难而死亡，因此 ATR 成为癌症治疗的潜在靶点。目前，基于 ATR 抑制剂（ATRi）的临床试验正在开展，但尚未建立有效的治疗方案。

Pseudoscience has recently re-emerged in the U.S. While much of it concerns vaccines, an "oldie" is again making the rounds: ...

Extended cash runway into late 2027, beyond a potentially registration-enabling azenosertib data readout from DENALI Part 2Planned workforce ...

Northwestern Medicine scientists have uncovered new details explaining how poxviruses manipulate host cells to enhance their ...

Announcing a new article publication for Zoonoses journal. Methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin ...

Previously, it was believed that these SMC motors, which create loops in DNA, could only move in a single direction. This groundbreaking discovery, published in Cell, provides crucial insights into ...

T cells play a pivotal role in the immune system by transforming into powerful effector cells that combat pathogens. This transformation requires rapid proliferation, during which DNA replication ...