The phase 1 trial is testing the safety tolerability, pharmacokinetics, and pharmacodynamics of PVT201 in healthy volunteers and patients.

Between 2001 to 2011, annual age-adjusted incidence increased from 0.55/100,000 to 0.78/100,000, demonstrating an increasing trend with age. Incidence peaks in individuals over 70 years of age ...

The decision to terminate the HYPERION trial reflects a loss of clinical equipoise, making it unethical to continue the placebo-controlled study.

Patients with ATTR-PN have a high rate of comorbidities and substantial direct healthcare and economic burdens, a study found.

AGEP can closely mimic generalized pustular psoriasis (GPP), requiring histopathologic confirmation and assessment of peripheral eosinophilia.

EGPA-associated nasal polyposis should be managed with medically (ie, biologics, anti-inflammatory drugs, and topical corticosteroids) and, in some cases, surgery. Nasal polyposis associated with ...

Associations between therapies and quality of life (QoL) in patients with generalized pustular psoriasis (GPP) can differ substantially.

Children with achondroplasia seem to be more challenged in the anterior-posterior direction, which might be linked to an anterior-shifted pelvis. No difference was observed in bipedal static postural ...

Pregnancies affected by multiple alloantibodies had significantly higher antibody titers and an increased need for intrauterine transfusion. Pregnancies complicated by multiple alloantibodies rather ...

In diagnosed cases of cutaneous mastocytosis, investigations to rule out systemic mastocytosis may be appropriate. A young child with a small chest lump and anemia was found to have cutaneous ...

A little more than a third (36.1%) of patients with Huntington disease (HD) and chorea are taking an anti-chorea medication, a study found.