This adds to the growing body of work, from mouse and fly models, implicating lipid metabolism in neurodegeneration, particularly AD,” Amita Sehgal, Perelman School of Medici ...

Enter SynPull, a new synaptosome imaging method developed by David Klenerman, John Danial, and colleagues at the University of Cambridge, England. SynPull combines single-molecule pull-down of ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

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Unknown. Multiple in silico algorithms yielded conflicting results.

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

We are pleased to present exclusive short films from “The Alzheimer’s Project,” sponsored by HBO Documentary Films and the National Institute on Aging of the National Institutes of Health, with ...

Over the past decade, cryo-electron microscopy has afforded scientists an unprecedented view deep into the core of tau fibrils, revealing shapes that track with different neurodegenerative diseases ...

"The neurologist diagnosed conversion disorder (see Medline). I should not have believed that. We went to counseling sessions for a year but nothing happened." —Caregiver. Families with eFAD tell ...