This transgenic model of tauopathy expresses MAPT with the P301S mutation, which is associated with autosomal-dominant disease in humans. The hTau.P301S model recapitulates several molecular, cellular ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

This has led to the commonly used term “parkinsonism plus syndrome.” A few such syndromes that are well described and, like PD, are thought to be related to the abnormal accumulation of proteins such ...

Louis, suggest that it could. Strange as it may sound, in mouse models of amyloidosis and tauopathy, huffing xenon lowered plaques and ameliorated neurodegeneration. How did the gas do this? By ...