通过对TP53研究的延展和借鉴，研究人员有望在更广泛的癌症基因研究中找到新的突破口。这项研究标志着癌症基因研究从单一突变分析向系统性 ...

Attempts to reactivate the gene have been challenging, but science has reached the point where early clinical trials are looking at drugs that may impact its function. In addition, those who have ...

TP53 is the gene that encodes the p53 protein. p53 refers to the protein product of the TP53 gene. The traditional view of cancer development, driven by oncogene activation and tumor suppressor ...

The results revealed that TP53mut/del patients had significantly worse outcomes compared to those with the wild-type TP53 gene. Specifically, the 2-year cumulative incidence of relapse (CIR) was 46.2% ...

2 North West Thames Regional Genetics Service, Kennedy-Galton Centre, London North West University Healthcare NHS Trust, Harrow, UK This is an open access article distributed in accordance with the ...