When STING is triggered, TANK-binding kinase (TBK1 ... “This paper shows the good and bad activity coming from different parts of the protein. So conceivably, you can selectively manipulate either one ...

How does the body react to insect bites or stings? Female mosquitoes bite because they need the protein in blood to develop ...

Work at IFM Due Inc. has led to the identification of stimulator of interferon genes protein receptor (STING; TMEM173) antagonists reported to be useful for the treatment of cancer, systemic lupus ...

The discovery of a protein’s contribution to the development of T-cells in the spleen and thymus could lead to new treatment strategies for immunodeficiency diseases. Despite its name ...

such as the cGAS-STING pathway and the NF-κB pathway. On the other hand, it phosphorylates regulatory many cellular and viral proteins for promoting the lytic cycle. This paper reviews the research ...

HDAC6 negatively modulates cGAS-STING signaling. HDAC6 interacts with and deacetylates TRIM56 at K110, thereby impairing cGAS monoubiquitination. Viral protein US3 phosphorylates HDAC6 to modulate the ...