Cell 153, 1094-1107. STING Activation by cGAMP. cGAMP has been shown by the Zhijian Chen lab to bind the signaling protein STING with subsequent activation of the IFN pathway. Our structural studies ...

The cGAS-STING pathway begins with an enzyme called cGAS-sensing double-stranded DNA present in the cytosol. It triggers a molecular messenger called cGAMP, which activates a protein called STING.

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

View Full Profile. Learn about our Editorial Policies. When STING is triggered, TANK-binding kinase (TBK1) activates and leads to interferon production. However, Tan and his team wanted to identify ...

An artist's impression of cGAS-STING pathway response model for micronucleus. Before, cGAS's accumulation in micronuclei was considered to be an indicator of cGAS activation. Now, it was found ...

Previous studies have mapped out the cytoplasmic cGAS-STING pathway in the cytoplasm, known for responding to foreign nucleic acids, such as double-stranded DNA. Micronuclei—or MN, abnormal ...

Metastasis returned when both ENPP1 and STING were inactivated, showing that ENPP1’s antimetastatic effects depended on the STING pathway. 2 ENPP1 serving as an on-off switch for metastasis is ...

TFEB and TFE3 are found throughout the animal kingdom, suggesting that the STING-induced autophagy-lysosome pathway is ...

Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...