The fatality is considered to be related to the drug treatment, according to the biotech, which is developing the STING agonist in collaboration with GSK under the terms of a $1.3 billion option ...
The activation of the intracellular transmembrane receptor stimulator of interferon genes (STING) has shown antitumoral effects in murine cancer models.
In 2013, a synthetic STING agonist, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), showed tremendous anticancer efficacy in mice but failed in human clinical trials because the murine and human ...
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Curadev Announces First Treatment Cycle Completion for the First Patient Dosed in a Phase 1a/b Clinical Trial of Allosteric STING Agonist CRD3874-SIThe dosing of patients with advanced sarcoma and Merkel cell carcinoma by intravenous infusion of Curadev's systemic allosteric STING agonist, CRD3874-SI, has been initiated in a Phase 1a/b dose ...
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