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As many as half of the disease-associated single-nucleotide mutations in the coding regions of genes do not alter specific amino acids in the protein, but rather affect RNA splicing; for example ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

After a gene is transcribed from DNA to RNA, extraneous sections ... "We know that splicing is dependent on enzymes, and any mutation that disrupts the concentration of enzymes has dramatic ...

While it's known that HD is caused by an abnormal expansion of cytosine, adenine and guanine nucleotide repeats in the DNA of the gene responsible for HD, how this mutation interferes with ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

While it's known that HD is caused by an abnormal expansion of cytosine, adenine and guanine nucleotide repeats in the DNA of the gene responsible for HD, how this mutation interferes with ...

While it's known that HD is caused by an abnormal expansion of cytosine, adenine and guanine nucleotide repeats in the DNA of the gene responsible for HD, how this mutation interferes with ...