What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Then the RNA binding protein communicates to the splicing machinery to include or not include the exon into the mRNA,” Cooper explained. The fit between a splice site and the spliceosome components ...

How does the splicing machinery distinguish between exons ... the exclusion of that exon under other conditions. Specific RNA Sequences Are Required for Regulation of Alternative Splicing If ...

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Alternative splicing (AS), a critical process for gene expression regulation, allows a single precursor ...

A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

The 3D structures into which DNA is ordered make certain genes more or less accessible to the machinery that ... where high concentrations of splicing enzymes make RNA splicing particularly ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

For some genes, the abundance of the circular RNA exceeds that of the associated linear mRNA ... These circular RNAs are generated when the pre-mRNA splicing machinery “backsplices” and joins a splice ...

In this webinar, Dr. Megan L Noonan will present her research on the role of alternative splicing in kidney disease progression, discussing how she used nanopore RNA sequencing to accurately detect ...

The study, "Global impact of unproductive splicing on human gene expression levels and traits," was supported by funding from the National Institutes of Health (grants R01GM130738, R01HG011067 ...

In this process, adenosine deaminases acting on RNA (ADARs) convert adenosine (A) to inosine (I) by hydrolytic deamination. Since inosine is interpreted as guanosine (G) by the cellular machinery, ...