Several mechanisms have evolved that regulate the biogenesis of specific classes of small RNA using variations on the same core processing machinery. Most animals encode a single Dicer protein ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

Alternative pathways of RNA processing are regulated in response to signaling cues often coordinating expression of gene networks in response to physiological change including in development and ...

Most of these proteins are RNA-binding proteins that are involved in distinct steps of RNA processing, maturation, transport and the regulation of RNA stability and translation. Interestingly ...

A new study from the Kowalinski group at EMBL Grenoble characterized the structure of an important trypanosomal protein ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies protein synthesis and impacts RNA processing in Alzheimer's ...

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other ...

Our laboratory carried out research in two areas. In one, we studied the structure and mechanism of activity of the catalytic RNA moiety of the RNA processing enzyme ribo-nuclease P (Rnase P). In the ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

Alterations in RNA-binding protein TDP-43 and m6A RNA modifications disrupt RNA processing, leading to gene regulation errors. These findings suggest potential therapeutic targets for HD and ...

Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification. Nature Neuroscience , 2025; DOI: 10.1038/s41593-024-01850-w Cite This Page : ...