Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo.I suggest that ∼ 90% of Pol II initiation events in ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

Anillin (ANLN), a mitotic protein that regulates contractile ring assembly, has been reported as an oncoprotein. However, the function of ANLN in cancer cells, especially in the nucleus, has not been ...

If your genes could set an alarm clock, EZH1 might be the one ringing the bell. A new study has revealed how this ...

EZH1 is a key regulator of circadian rhythms, stabilizing gene transcription and modifying chromatin to maintain genetic ...

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...

This unwinding of the helix is caused by an enzyme (helicase enzyme). The enzyme RNA polymerase attaches to the DNA in a non-coding region just before the gene. RNA polymerase moves along the DNA ...