CRT contains a cleavable signal sequence in this domain, which is found in proteins that are marked for targeting to the ER, and the presence of this signal indicates that CRT is transported into ...
The technological demand for bioconjugate chemistry is fueled by the exponential growth of pharma and biopharma. The protein targeting chemistry comprises varying aspects, including precision protein ...
This resistance often emerges in metastatic tumours, because cancer cells can evolve in ways that allow them to survive, such ...
We have identified the IRE1/XBP1 branch of the Unfolded Protein Response (UPR) or endoplasmic reticulum (EnR) stress response as a previously unexplored therapeutic vulnerability in MYC-driven breast ...
Vepdegestrant is an investigational, orally bioavailable PROTAC protein degrader designed to specifically target and degrade the estrogen receptor (ER) for the treatment of patients with ER ...
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