Intron recognition always takes place during the splicing event itself, which is catalyzed by the large spliceosomal machinery comprising five RNA molecules and >100 proteins. In contrast ...

When this mechanism is disrupted, the blueprints used by the cell to produce proteins are inaccurately edited through a process called splicing. The study, led by Goethe University Frankfurt ...

we need to know the relative differences between the two isoforms of the alternative splicing event at the protein level, which exons are involved relative to the full transcript, and what protein ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Splicebio S.L. has gained IND clearance from the FDA for its lead program SB-007, a protein splicing gene therapy to address the root genetic cause of Stargardt disease. The company plans to initiate ...

Proteins can express and repress genes, manipulate their own genetic code and other proteins, regulate neural network connections, facilitate gene splicing, and manage the flow of proteins between ...

The conditions required for in vitro splicing are generally non-physiological and most, if not all, group II introns require proteins for splicing in vivo. Figure 4. Plant mitochondria maturases.

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

Here the authors convincingly identify and characterize the SERBP1 interactome and further define its role in the nucleus, where it is associated with complexes involved in splicing, cell division, ...

Serpine1 mRNA-binding protein 1 (SERBP1) is a unique member of this group, being mostly disordered and lacking canonical RNA-binding domains. We defined SERBP1’s interactome, uncovered novel roles in ...