FMC-220 is a first-in-class covalent activator of p53 Y220C designed to address potency and tolerability challenges of non-covalent approaches In preclinical studies, FMC-220 demonstrated ...

the first covalent p53 Y220C activator designed to overcome the limitations of potency and durability seen in non-covalent approaches. FMC-220 represents a groundbreaking advancement, with the ...

Spatially resolved protein profiling in pancreatic adenosquamous carcinoma. Age, number of genomic alterations (GA) per tumor, and alteration frequency of select commonly altered genes based on TP53 ...