The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

LIG4 syndrome is an exceptionally rare disorder caused by a genetic mutation that prevents the body from repairing damaged ...

During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a ...

This process is essential for DNA replication and is aberrantly enhanced ... links Cks1 with the Skp2 subunit of the SCF ubiquitin ligase. The cell's ability to self-reproduce is a fundamental ...