艾滋病毒是如何操纵细胞的？德国科学家发现治愈线索
红枫湾APP：医学快讯网消息，德国姆霍兹RNA 感染研究所和雷根斯堡大学的一个科学家团队发表在《自然结构与分子生物学》杂志上的一项新研究，揭示了HIV-1 为维持自身生存是如何巧妙地劫持细胞机制的。
生物谷18 天
Nature子刊：揭示HIV-1在抑制宿主细胞防御的同时确保其自身复制的新策略
另一个重要发现是HIV-1病毒基因组中关键的“移码位点”附近的复杂RNA结构。这个移码位点对于这种病毒产生两种关键蛋白Gag和Gag-Pol的正确比例至关 ...
Nature1 年
Update on the laboratory diagnosis and monitoring of HIV infection
Some HIV treatment regimens are very difficult for ... viral constructs that have been derived by splicing patient viral pol gene sequences into a well-characterized viral vector.
BioWorld3 天
Merck Sharp & Dohme describes new Gag polyprotein (HIV-1)/protein Pol dimerization inducers
Merck Sharp & Dohme LLC has identified targeted activator of cell kill (TACK) compounds acting as Gag polyprotein (HIV-1)/protein Pol dimerization inducers reported to be useful for the treatment of ...
Science Daily24 天
Decoding HIV's tactics
Gag and Gag-Pol, which are necessary for assembling infectious particles and replication of HIV-1. The researchers demonstrated that this extended RNA fold not only promotes ribosome collisions ...
Medscape19 年
Frequency of Drug-Resistant Variants of HIV-1 Coexistent With Wild-Type in Treatment-Naive ...
Point mutations at codon 184 (Met→ Val/Ile) in the pol gene of HIV are known to confer high-level resistance to lamivudine. While amplification of wild-type sequence (Met) was observed in all of ...
来自MSN24 天
Decoding HIV's tactics: RNA structures provide new insights into how virus hijacks cells
Gag and Gag-Pol, which are necessary for assembling infectious particles and replication of HIV-1. The researchers demonstrated that this extended RNA fold not only promotes ribosome collisions ...