Scientists at Purdue University and the University of Minnesota have solved the three-dimensional structure of the central component of a biological "motor" that powers the DNA packaging system in a ...

One can also argue that large DNA viruses arose through a regressive process whereby once-independent entities lost key genes over time and adopted a parasitic replication strategy. Finally ...

With only seven genes, the BK polyomavirus must use the host cell's DNA replication machinery to produce new viruses. Although the virus was discovered over 50 years ago, little is known about how ...

During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a ...

Northwestern Medicine scientists have uncovered new details explaining how poxviruses manipulate host cells to enhance their ...

Ancient viral DNA shapes early embryo development. ScienceDaily . Retrieved February 8, 2025 from www.sciencedaily.com / releases / 2025 / 01 / 250120113758.htm ...

One aspect that signals pandemic potential in a virus is having an RNA, rather than DNA, genome. That’s because the process of copying RNA typically doesn’t include a proofreader like DNA replication ...

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...

The extended copies create kinks in the DNA, making it more susceptible to breakage and replication errors ... the immune system that normally target viruses by damaging their DNA.

These analogs can interfere with DNA replication and induce cell death in rapidly dividing cancer cells or inhibit viral replication. Examples include: 5-Fluorouracil (5-FU): A pyrimidine analog used ...

Several antiviral and anticancer drugs target the incorporation of adenine into DNA or RNA. For example, some nucleoside analog drugs, such as vidarabine and fludarabine, mimic adenine and interfere ...