Arthur Kornberg compared DNA to a tape recording of ... is always in the 5'-to-3' direction, and replication is always continuous along the leading strand and discontinuous along the lagging ...

DNA replication is one of the most basic processes ... One of these original strands is called the leading strand, whereas the other is called the lagging strand. The leading strand is synthesized ...

Once the leading-strand polymerase resumes DNA synthesis, it catches up to the helicase and rapid template unwinding and replication can continue (Fig. 3). We have termed this fail-safe mechanism a ...

A team has unearthed new findings about what happens during the minutes and hours after a cell divides, expanding our understanding of human biology -- and potentially leading to better medicines.

“It’s a different way of thinking about replication ... DNA from E. coli bacteria. The first step in the process always sees the double helix “unzipping” into two strands — a “leading ...