The first section of the book, Cellular DNA Replication ... replication origin structure, pre-replicative complex assembly and activation, proteins at the replication fork and replication termination.

Therefore, DNA lesions cause regions of DNA to remain single-stranded (uncopied). Scientists use the term "stalled forks" for areas of replication forks where DNA polymerization is halted.

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

However, the process of DNA replication intrinsically disrupts nucleosomes ahead of the fork raising the question how chromatin structure is maintained across generations. Nucleosomes are re-assembled ...