DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides—whether to repair damaged tissue, replace old cells, or simply to help the ...

Combining long-read DNA sequencing with a predictive artificial intelligence model has provided new insights into DNA ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell ...

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells ...

Scientists at the Wellcome Sanger Institute uncovered DNA damage that can persist for years, evading repair mechanisms and ...

DNA damage can result in the genetic sequence being misread and copied during cell division -- known as DNA replication -- and this introduces permanent mutations that can contribute to the ...

ATR 激酶是应对 DNA 复制应激（RS）的关键调节因子，在癌细胞中，许多遗传突变会导致 RS 水平升高，而 ATR 在维持复制叉的稳定性和促进细胞存活方面发挥着重要作用。抑制 ATR 可使癌细胞因复制叉崩溃和有丝分裂灾难而死亡，因此 ATR 成为癌症治疗的潜在靶点。目前，基于 ATR 抑制剂（ATRi）的临床试验正在开展，但尚未建立有效的治疗方案。

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

Your body is a collection of cells carrying thousands of genetic mistakes accrued over a lifetime—many harmless, some bad and ...

The transfer of this principle to artificial cells is a challenge in synthetic biology. Advances in DNA nanotechnology now offer promising solutions. They allow the creation of novel transport ...

Old viral DNA, once thought to be gone forever, is reactivated in mammalian embryos, with each species showing unique variations. An atlas of transcription initiation reveals regulatory principles of ...