Kossel isolated cytosine from calf thymus tissues and found that it was a component of nucleic acids. This discovery, along with the identification of other nitrogenous bases, laid the foundation for ...
Unlike the canonical double helix, i-motifs form under specific conditions. They emerge when cytosine bases on the same DNA strand pair with each other, creating a unique structural feature.
The thymine-adenine (T-A) base pair is held together by fewer hydrogen bonds compared to the guanine-cytosine (G-C) base pair, which has three hydrogen bonds. The complementary base pairing in DNA ...
Now, researchers at Harvard University have designed a new class of adenine base editors (ABEs) that can efficiently turn A-T into G-C, opening up the majority of pathogenic point mutations for ...
These orientations vary across the four bases: adenine, guanine, cytosine and thymine. Furthermore, spin system simulations analyzed the electric field gradient data of adjacent bases, showing that ...
The gold standard technology that scientists use to detect DNA methylation is bisulfite genomic sequencing. It is a qualitative, quantitative, and efficient approach to identify methylated cytosine at ...