在该通路中，cGAS结合双链DNA并变得催化活跃，合成环状GMP-AMP（cGAMP），这是STING的强效激动剂。结合配体后，STING发生寡聚化并通过其C端尾部的保守 ...

cGAMP in turn bound to and activated the adaptor STING, resulting in the activation of transcription factor IRF3 and subsequent induction of interferon beta. Our ongoing studies have focused on ...

其功能与天然STING配体cGAMP类似。据这些作者披露，SR-717在黑色素瘤小鼠模型中显示了强效的抗肿瘤活性。根据这些发现，Pan等人研发了一种激动剂 ...

The cGAS-STING pathway begins with an enzyme called cGAS-sensing double-stranded DNA present in the cytosol. It triggers a molecular messenger called cGAMP, which activates a protein called STING.

This method allowed Chen to trace the events leading to STING activation and zero in on the missing piece. Their findings demonstrated that cytoplasmic DNA, not RNA, set off a chain of events. cGAMP ...

In 2013, a synthetic STING agonist, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), showed tremendous anticancer efficacy in mice but failed in human clinical trials because the murine and human ...

The first is cyclic GMP-AMP (cGAMP), a molecule that switches on STING when foreign DNA lurks in cells. The second is cGAS, the enzyme that enables the cells of mammals — including humans — to ...

The assay uses antibodies that selectively bind cGAMP in the presence of excess ATP and GTP. When the fluorescent tracer is displaced by cGAMP, a change in signal is achieved. The novel direct ...