To prepare a sample, DNA is fragmented into 100–200-base-pair pieces, and then adaptors of known sequence, often poly(A) tails, are attached to the ends of DNA fragments. “We can capture that ...
The sequence of base pairs in DNA determines the genetic code, which is read in triplets (codons) to specify the amino acid sequence of proteins. The complementary nature of base pairing allows for ...
DNA sequencing is any chemical, enzymatic or technological procedure for determining the linear order of nucleotide bases in DNA ... often applies to the entire sequence determination pipeline ...
computing resolved bases that have both genetic and epigenetic information. This allows researchers to sequence all four DNA bases and distinguish between 5mC and 5hmC. Using the data analysis package ...
The research is published in the journal Nature. The study comprehensively analyzed "cis-regulatory elements" (CREs), which are the DNA sequences that regulate gene transcription. This work sheds ...