ApoE protein is a lipid-binding protein expressed at the highest levels in the liver and brain, where it binds directly to Aβ present in plaques. Of the three common APOE gene alleles ...

This adds to the growing body of work, from mouse and fly models, implicating lipid metabolism in neurodegeneration, particularly AD,” Amita Sehgal, Perelman School of Medici ...

Research indicates longer REM latency is associated with higher Alzheimer's biomarkers, pointing to its potential as an early ...

7,8 In the research domain, recombinant proteins like Aβ, tau, GLP1R, and ApoE are instrumental in advancing drug discovery and unraveling target interactions. 4,9–12 Leading the charge in ...

Apolipoprotein E (apoE), a crucial glycoprotein in CNS lipid metabolism, particularly its apoE4 isoform, significantly influences AD pathogenesis by affecting lipid-binding properties and impairing Aβ ...

Factor H (FH) regulates complement at the C3b level (B) through binding to apoE on Aβ deposits (structure of C3b: PDB 5FO7) (Chernyaeva, Ratti et al. 2023). (C) Structural model for apoE2-FH complex ...